Hélène Girouard

Title : Assistant professor
Adress : University of Montréal
C.P. 6128 – Downtown Branch
Montréal, Québec H3C 3J7
Pavillon Roger-Gaudry
Office : T-433-1
Phone : (514) 343-6111 # 32786
Email : helene_girouard@hotmail.com


Formation

B.Sc. Biology, UQAM; M.Sc. Biology, UQAM;

Ph.D. Physiology, University of Montréal (2002);

Postdoctoral Fellowships: Department of Neurology, Weill Medical College of Cornell University (2003-2006);

Department of Pharmacology, University of Vermont (2006-2008).


Research Themes

  • Cerebrovascular pharmacology in health and disease.
  • Mechanisms underlying cerebral neurovascular coupling.
  • Astrocyto-vascular communication.

Techniques

  • In vivo (cranial window) and in vitro (brain slices and isolated arteries) cerebrovascular pharmacology;
  • Cerebral blood flow monitoring using laser Doppler flowmetry;
  • In vivo et in vitro two-photon microscopy;
  • Vascular pharmacology on isolated and pressurized arteries;
  • Immunohistochemistry;
  • Molecular biology.

Present members

  • Eric Lizotte, technician
  • Clériston Farias Alves, M.Sc. student
  • Mélissa Beauvillier, trainee


Publications

  • Girouard H, Lessard A, Capone C, Milner TA, Iadecola C. The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic.Am J Physiol Heart Circ Physiol. 2008; 294(1): H156-H163.
  • Girouard H, Park L, Anrather J, Zhou P, Iadecola C. Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II. ATVB. 2007; 27(2): 303-309.
  • Girouard H, Park L, Anrather J, Zhou P, Iadecola C. Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through nox-2-derived radicals. ATVB. 2006; 26(4):826-832.
  • Girouard H, Iadecola C. Invited Review: Neurovascular coupling in the normal brain and in hypertension, stroke and Alzheimer disease. J. Appl. Physiol. 2006; 100(1): 328-335.
  • Girouard H, de Champlain J. Acute and chronic effects of free radicals on alpha1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats. J. Hypertens. 2005;23: 807-814.
  • Girouard H, Denault C, Chulak C, de Champlain J. Treatment by n-acetylcysteine and melatonin increases cardiac baroreflex and improves antioxidant reserve. Am. J. Hypertens. 2004; 17(10): 947­954.
  • Girouard H, de Champlain J. Inhibitory effect of melatonin on alpha1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats. Am. J. Hypertens. 2004; 17(4): 339-346.
  • Girouard H, Chulak C, Lejossec M, De Champlain J. N-acetylcysteine treatment improves NO and alpha-adrenergic pathways in Mesenteric Artery of Spontaneously Hypertensive Rats. Am. J. Hypertens. 2003; 16(7): 577-584.
  • Girouard H, Chulak C, Lejossec M, Lamontagne D, De Champlain J. Chronic antioxidant treatment improves sympathetic functions and ß-adrenergic pathway in the spontaneously hypertensive rats. J Hypertens. 2003; 21(1): 179-188.