Publications récentes


The effects of anti-VEGF and kinin B1 receptor blockade on retinal inflammation in laser-induced choroidal neovascularization.
Hachana S, Fontaine O, Sapieha P, Lesk M, Couture R, Vaucher E. Br J Pharmacol. 2020 May;177(9):1949-1966. doi:10.1111/bph.14962


Reciprocal Regulatory Interaction between TRPV1 and Kinin B1 Receptor in a Rat Neuropathic Pain Model.
Cernit V, Sénécal J, Othman R, Couture R. Int J Mol Sci. 2020 Jan 27;21(3):821. doi: 10.3390/ijms21030821.


Differential Expression of Kinin Receptors in Human Wet and Dry Age-Related Macular Degeneration Retinae.
Othman R, Berbari S, Vaucher E, Couture R. Pharmaceuticals (Basel). 2020 Jun 24;13(6):130. doi: 10.3390/ph13060130.


Diabetes-induced inflammation and vascular alterations in the Goto-Kakisaki rat retina.
Hachana S, Pouliot M, Couture R, Vaucher E. Curr Eye Res. 2020 Aug;45(8):965-974. doi: 10.1080/02713683.2020.1712730


Neuroligin-1 is altered in the hippocampus of Alzheimer’s disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers.
Dufort-Gervais J, Provost C, Charbonneau L, Norris C, Calon F, Mongrain V & Brouillette J (2020) Scientific Reports, 10:6956


Tau hyperphosphorylation induced by the anesthetic agent ketamine/xylazine involved the calmodulin-dependent protein kinase II.
Hector A, McAnulty C, Piché-Lemieux MÉ, Alves-Pires C, Buée-Scherrer V, Buée L & Brouillette J (2020) FASEB J, 34:2968-2977


A novel cationic N-type calcium channel inhibitor active against neurogenic inflammation.
Lee SK*, Jo S*, Talbot S, Puopolo M, Liu P, Jacquemont T, Lee J, Woolf CJ, and Bean BP.
eLife


Down-regulation of MHC class II by ubiquitination is required for the migration of CD206+ DCs to skin-draining lymph nodes.
Majdoubi A, Lee JS, Balood M, Sabourin A, DeMontigny A, Kishta OA, Moulefera M, Galbas T, Yun TJ, Talbot S, Ishido S, Cheong C, Thibodeau J.
Journal of Immunology. 2019. PMID: 31659013


Profiling of how nociceptor neurons detect danger; new and old foes. 
Crosson T, Roversi K, Balood M, Othman R, Ahmadi M, Wang JC, Pereira PJS, Couture R, Latini AS, Prediger RDS, Rangachari M, Seehus CR, Foster SL, Talbot S.
Journal of Internal Medicine. 2019. PMID: 31282104


Neurons and microglia; a sickly-sweet duo in diabetic pain neuropathy.
Rajchgot T, Thomas S, Wang JC, Ahmadi M, Balood M, Crosson T, Dias JP, Couture R, Claing A and Talbot S.
Frontiers in Neuroscience. 2019. PMID: 30766472


Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.
Latini A, Couture R, Campos MM and Talbot S.
Oxidative Medicine and Cellular Longevity. 2019. PMID: 30723534


Dysregulation of ER stress response and calcium homeostasis in human iPSC-derived neurons carrying the LRRK2 G2019S mutation.
Korecka JA, Talbot S, Levy S, De Leeuw SM, Terpstra ML, Osborn TM, Hallett PJ, Jodelka FM, Woolf CJ, Hastings ML, Isacson O.
Stem Cell Report. 2019. PMID: 30595548


The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Cronin SJF, Seehus CR, Weidinger A, Talbot S, Reissig S, Pierson Y, Longhi MS, McNeill E, Kreslavsky T, Kogler M, Seifert M, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Andrews N, Latremoliere A, Latini A, Lametschwandtner G, Busslinger M, Weiss G, Robson SC, Waisman A, Costigan M, Kozlov AV, Channon KM, Johnsson K, Woolf CJ, and Penninger JM.
Nature. 2018. PMID: 30405245


Sense and immunity: context-dependent neuro-immune interplay.
Foster SL, Seehus CR, Woolf CJ and Talbot S.
Frontiers in Immunology. 2017. PMID: 29163530.


The role of membrane-bound metal ions in toxicity of a human cancer cell-active pore-forming toxin Cry41Aa from Bacillus thuringiensis.
Domanska B, Fortea E, West MJ, Schwartz, JL, Crickmore N.
Toxicon. 2019 Jun 7;167:123-133. doi: 10.1016/j.toxicon.2019.06.003. PMID: 31181295


Cry6Aa1, a Bacillus thuringiensis nematocidal and insecticidal toxin, forms pores in planar lipid bilayers at extremely low concentrations and without the need of proteolytic processing.
Fortea E, Lemieux V, Potvin L, Chikwana V, Griffin S, Hey T, McCaskill D, Narva K, Tan SY, Xu X, Vachon V, Schwartz JL.
J Biol Chem. 2017 Aug 11;292(32):13122-13132. doi: 10.1074/jbc.M116.765941. PMID: 28623231


Bradykinin Type 1 Receptor – Inducible Nitric Oxide Synthase: A New Axis Implicated in Diabetic Retinopathy.
Othman R, Vaucher E, Couture R.
Front Pharmacol. 2019 Mar 29;10:300. doi: 10.3389/fphar.2019.00300. eCollection 2019


Inhibition of overexpression of Giα proteins and nitroxidative stress contribute to sodium nitroprusside-induced attenuation of high blood pressure in SHR.
Hossain E, Sarkar O, Li Y, Anand-Srivastava MB.
Physiol Rep. 2018 Mar;6(6):e13658. doi: 10.14814/phy2.13658.


Natriuretic peptide receptor-C-mediated attenuation of vascular smooth muscle cell hypertrophy involves Gqα/PLCβ1 proteins and ROS-associated signaling.
Jain A, Anand-Srivastava MB.
Pharmacol Res Perspect. 2018 Feb;6(1). doi: 10.1002/prp2.375.


Natriuretic peptide receptor-C activation attenuates angiotensin II-induced enhanced oxidative stress and hyperproliferation of aortic vascular smooth muscle cells.
Madiraju P, Hossain E, Anand-Srivastava MB.
Mol Cell Biochem. 2018 Nov;448(1-2):77-89. doi: 10.1007/s11010-018-3316-x. Epub 2018 Feb 7.


Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis.
Hertig V, Matos-Nieves A, Garg V, Villeneuve L, Mamarbachi M, Caland L, Calderone A.
J Cell Physiol. 2018 Apr;233(4):3218-3229. doi: 10.1002/jcp.26165. Epub 2017 Sep 27.


The Biological Role of Nestin(+)-Cells in Physiological and Pathological Cardiovascular Remodeling.
Calderone A.
Front Cell Dev Biol. 2018 Feb 14;6:15. doi: 10.3389/fcell.2018.00015. eCollection 2018.


Dual functions of ARP101 in targeting membrane type-1 matrix metalloproteinase : Impact on brain cancer cell invasion and autophagy signaling.
Desjarlais M, ANNABI B
Chemical Biology & Drug Design, 2018 (sous presse)


Static Hand Posture Classification Based on the Biceps Brachii Muscle Synergy Features.
He L, Mathieu PA.
J Electromyog and Kinesiol, doi: https://doi.org/10.1016/j.jelekin.2018.10.003, 2018


Phase singularity detection through phase map interpolation: Theory, advantages and limitations.
Jacquemet V.
Comput Biol Med. 2018 jul 24. Pii: S0010-4825(18)30205-1.
Doi: 10.1016/j.compbiomed.2018.07.014


In silico study of multicellular automaticity of heterogeneous cardiac cell monolayers: Effects of automaticity strength and structural linear anisotropy.
Duverger JE, Jacquemet V, Vinet A, Comtois P.
PLoS Comput Biol. 2018 Mar 12;14(3):e1005978. doi: 10.1371/journal.pcbi.1005978. eCollection 2018 Mar. PMID: 29529023 Free PMC Article


Novel criterion for the differential diagnosis of wide QRS complexes and wide complex tachycardia using the initial activation of QRS on leads V1 and V2: Differential diagnosis of wide QRS based on V1-V2.
El Hajjaji I, Becker G, Kus T, Vinet A, Berkovitz A, Sturmer M.
J Electrocardiol. 2018 Jul – Aug;51(4):700-706. doi: 10.1016/j.jelectrocard.2018.04.015. Epub 2018 Apr 25.


Sense and immunity: context-dependent neuro-immune interplay.
Foster SL, Seehus C, Woolf CJ and Talbot S*.
Frontier in Immunology. 2017. 3;8:1463. doi: 10.3389/fimmu.2017.01463. PMID: 29163530. *Senior author.


The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. 
Cronin SJF, Seehus CR, Weidinger A, Talbot S, Reissig S, Pierson Y, Longhi MS, McNeill E, Kreslavsky T, Kogler M, Seifert M, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Andrews N, Latremoliere A, Latini A, Lametschwandtner G, Busslinger M, Weiss G, Robson SC, Waisman A, Costigan M, Kozlov AV, Channon KM, Johnsson K, Woolf CJ, Penninger JM.
Nature. 2018.


Microglia drives diabetic pain neuropathy.
Rajchgot T, Thomas S, Wang JC, Ahmadi M, Balood M, Crosson T, Dias JP, Couture R, Claing A and Talbot S*.
Frontiers in Neuroscience. Submitted. 2018/10/15. PIN: FTN1025-16


Dysregulation of ER stress response and calcium homeostasis in human iPSC-derived neurons carrying the LRRK2 G2019S mutation.
Korecka JA, Talbot S, Levy S, De Leeuw SM, Terpstra ML, Osborn TM, Hallett PJ, Jodelka FM, Woolf CJ, Hastings ML, Isacson O.
Stem Cell Report. In revision. October 2018. PIN: CSC-2310-17R2


Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration. Oxidative Medicine and Cellular Longevity.
Talbot S, Latini A, Couture R, Campos MM.
Submitted. 2018/10/15.


Cardiotrophin-like Cytokine Increases Macrophage-Foam Cell Transition.
Pasquin S, Laplante V, Kouadri S, Milasan A, Mayer G, Tormo AJ, Savin V, Sharma M, Martel C, Gauchat JF.
J Immunol. 2018 Oct 15;201(8):2462-2471. doi: 10.4049/jimmunol.1800733. Epub 2018 Sep 12.


Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity.
Pasquin S, Chehboun S, Dejda A, Meliani Y, Savin V, Warner GJ, Bosse R, Tormo A, Mayer G, Sharma M, Sapieha P, Martel C, Gauchat JF.
Sci Rep. 2018 Mar 5;8(1):3990. doi: 10.1038/s41598-018-22400-y.


The many faces of vascular cognitive impairment.
Girouard H, Munter L M.
J Neurochem. 2018 Mar;144(5):509-512. doi: 10.1111/jnc.14287. Epub 2018 Feb 11.


Differential effect of angiotensin II and blood pressure on hippocampal inflammation in mice.
Iulita MF, Vallerand D, Beauvillier M, Haupert N, A Ulysse C, Gagné A, Vernoux N, Duchemin  S, Boily M, Tremblay MÈ, Girouard H.
J Neuroinflammation. 2018 Feb 28;15(1):62. doi: 10.1186/s12974-018-1090-z.


Arterial stiffness induced by carotid calcification leads to cerebral gliosis mediated by oxidative stress.
Sadekova N, Iulita MF, Vallerand D, Muhire G, Bourmoum M, Claing A, Girouard H.
J Hypertens. 2018 Feb;36(2):286-298. doi: 10.1097/HJH.0000000000001557.


Arterial stiffness, cognitive impairment and dementia: confounding factor or real risk?
Iulita MF, Noriega de la Colina A, Girouard H.
J Neurochem. 2018 Mar;144(5):527-548. doi: 10.1111/jnc.14235. Epub 2017 Nov 27.


Segregation of dopamine and glutamate release sites in dopamine neuron axons: regulationby striatal target cells.
Fortin G, Ducrot C, Giguère N, Kouwenhoven WM, Bourque MJ, Pacelli C, Varaschin RK, Brill M, Singh S, Wiseman PW, Trudeau LÉ.
FASEB J. 2018 Jul 16:fj201800713RR. doi: 10.1096/fj.201800713RR. [Epub ahead of print]


On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson’s Disease.
Giguère N, Burke Nanni S, Trudeau LE.
Front Neurol. 2018 Jun 19;9:455. doi: 10.3389/fneur.2018.00455. eCollection 2018.


Comparative analysis of Parkinson’s disease-associated genes in mice reveals altered survival and bioenergetics of Parkin-deficient dopamine neurons.
Giguère N, Pacelli C, Saumure C, Bourque MJ, Matheoud D, Levesque D, Slack RS, Park DS, Trudeau LÉ
J Biol Chem. 2018 Jun 22;293(25):9580-9593. doi: 10.1074/jbc.RA117.000499. Epub 2018 Apr 26.


Histamine H3 Receptors Decrease Dopamine Release in the Ventral Striatum by Reducing the Activity of Striatal Cholinergic Interneurons.
Varaschin RK, Osterstock G, Ducrot C, Leino S, Bourque MJ, Prado MAM, Prado VF, Salminen O, Rannanpää Née Nuutinen S, Trudeau LE
Neuroscience. 2018 Apr 15;376:188-203. doi: 10.1016/j.neuroscience.2018.01.027. Epub 2018 Jan 31.


High and escalating levels of cocaine intake are dissociable from subsequent incentive motivation for the drug in rats.
Allain F, Bouayad-Gervais K, Samaha AN.
Psychopharmacology (Berl). 2018 Jan;235(1):317-328. doi: 10.1007/s00213-017-4773-8. Epub 2017 Oct 31.
PMID:29085961


Varying the rate of intravenous cocaine infusion influences the temporal dynamics of both drug and dopamine concentrations in the striatum.
Minogianis EA, Shams WM, Mabrouk OS, Wong JT, Brake WG, Kennedy RT, du Souich P, Samaha AN.
Eur J Neurosci. 2018 May 14. doi: 10.1111/ejn.13941. [Epub ahead of print]
PMID: 29757478


Revisiting long-access versus short-access cocaine self-administration in rats: intermittent intake promotes addiction symptoms independent of session length.
Allain F, Samaha AN.
Addict Biol. 2018 Jun 19. doi: 10.1111/adb.12629. [Epub ahead of print]
PMID: 29920865


Expression, distribution and function of kinin B1 receptor in the rat diabetic retina.
Hachana S, Bhat M, Sénécal J, Huppé-Gourgues F, Couture R, Vaucher E.
Br J Pharmacol. 2018 Mar;175(6):968-983. doi: 10.1111/bph.14138.


Periostin, a signal transduction intermediate in TGF-β-induced EMT in U-87MG human glioblastoma cells, and its inhibition by anthocyanidins.
Ouanouki A, Lamy S, Annabi B. (2018)
Oncotarget, 2018, 9 (31):22023-22037


Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
Chennupati V, Veiga DF, Maslowski KM, Andina N, Tardivel A, Yu EC, Stilinovic M, Simillion C, Duchosal MA, Quadroni M, Roberts I, Sankaran VG, MacDonald HR, Fasel N, Angelillo-Scherrer A, Schneider P, Hoang T, Allam R.
J Clin Invest. 2018 Apr 2;128(4):1597-1614. doi: 10.1172/JCI94956. Epub 2018 Mar 19.
PMID: 29408805


Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.
Smith MJ, Ottoni E, Ishiyama N, Goudreault M, Haman A, Meyer C, Tucholska M, Gasmi-Seabrook G, Menezes S, Laister RC, Minden MD, Marschalek R, Gingras AC, Hoang T, Ikura M. Nat Commun. 2017 Oct 23;8(1):1099. doi: 10.1038/s41467-017-01326-5.
PMID: 29062045


Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling.
Zhang X, Lavoie G, Méant A, Aubert L, Cargnello M, Haman A, Hoang T, Roux PP.
Mol Cell Biol. 2017 Mar 17;37(7). pii: e00357-16. doi: 10.1128/MCB.00357-16. Print 2017 Apr 1.
PMID: 28096188


The tyrosine phosphatase STEP is involved in age-related memory decline.
Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn A, Norris CM, Ferland G, Bézard E, Gaudreaud P, Lombroso P & Brouillette J (2018)
Current Biology; 28(7): 1079-1089


A three-way inter-molecular network accounts for the CaVα2δ1-induced functional modulation of the pore-forming CaV1.2 subunit.
Briot J, Mailhot O, Bourdin B, Tétreault MP, Najmanovich R, Parent L.
J Biol Chem. 2018 Mar 27. pii: jbc.RA118.001902. doi: 10.1074/jbc.RA118.001902.


Biophysical evidence for differential gallated green tea catechins binding to membrane type-1 matrix metalloproteinase and its interactors.
Djerir D, Iddir M, Bourgault S, Lamy S, ANNABI B (2018)
Biophysical Chemistry 234:34–41


High and escalating levels of cocaine intake are dissociable from subsequent incentive motivation for the drug in rats.
Allain F, Bouayad-Gervais K, Samaha AN.
Psychopharmacology (Berl). 2018 Jan;235(1):317-328. doi: 10.1007/s00213-017-4773-8. Epub 2017 Oct 31.
PMID: 29085961


Analgésie. In Anesthésie-réanimation en chirurgie thoracique
Garneau S, Girard F, Beaulieu P.
Edit. Bussière J & Léone M. Arnette, 2017; p. 421-440. ISBN 10 : 2718413832.