Hélène Girouard

Formation

B.Sc. Biology, UQAM; M.Sc. Biology, UQAM;

Ph.D. Physiology, University of Montréal (2002);

Postdoctoral Fellowships: Department of Neurology, Weill Medical College of Cornell University (2003-2006);

Department of Pharmacology, University of Vermont (2006-2008).

Research Themes

• Cerebrovascular pharmacology in health and disease.
• Mechanisms underlying cerebral neurovascular coupling.
• Astrocyto-vascular communication.

Techniques

• In vivo (cranial window) and in vitro (brain slices and isolated arteries) cerebrovascular pharmacology;
• Cerebral blood flow monitoring using laser Doppler flowmetry;
• In vivo et in vitro two-photon microscopy;
• Vascular pharmacology on isolated and pressurized arteries;
• Immunohistochemistry;
• Molecular biology.

Present members

• Eric Lizotte, technician
• Clériston Farias Alves, M.Sc. student
• Mélissa Beauvillier, trainee

Publications

• Girouard H, Lessard A, Capone C, Milner TA, Iadecola C. The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic.Am J Physiol Heart Circ Physiol. 2008; 294(1): H156-H163.
• Girouard H, Park L, Anrather J, Zhou P, Iadecola C. Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II. ATVB. 2007; 27(2): 303-309.
• Girouard H, Park L, Anrather J, Zhou P, Iadecola C. Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through nox-2-derived radicals. ATVB. 2006; 26(4):826-832.
• Girouard H, Iadecola C. Invited Review: Neurovascular coupling in the normal brain and in hypertension, stroke and Alzheimer disease. J. Appl. Physiol. 2006; 100(1): 328-335.
• Girouard H, de Champlain J. Acute and chronic effects of free radicals on alpha1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats. J. Hypertens. 2005;23: 807-814.
• Girouard H, Denault C, Chulak C, de Champlain J. Treatment by n-acetylcysteine and melatonin increases cardiac baroreflex and improves antioxidant reserve. Am. J. Hypertens. 2004; 17(10): 947­954.
• Girouard H, de Champlain J. Inhibitory effect of melatonin on alpha1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats. Am. J. Hypertens. 2004; 17(4): 339-346.
• Girouard H, Chulak C, Lejossec M, De Champlain J. N-acetylcysteine treatment improves NO and alpha-adrenergic pathways in Mesenteric Artery of Spontaneously Hypertensive Rats. Am. J. Hypertens. 2003; 16(7): 577-584.
• Girouard H, Chulak C, Lejossec M, Lamontagne D, De Champlain J. Chronic antioxidant treatment improves sympathetic functions and ß-adrenergic pathway in the spontaneously hypertensive rats. J Hypertens. 2003; 21(1): 179-188.