Titre : | Professeure sous octroi agrégée |
Adresse : | Pavillon Roger Gaudry C.P. 6128 – Succursale Centre-ville Montréal (Québec) H3C 3J7 |
Local : | T-433-1 |
Téléphone : | 514 343-6111 poste 32786 |
Courriel : | helene_girouard@hotmail.com |
Formation
- B.Sc. en biologie, UQAM (1993)
- M. Sc. Biologie, UQAM (1996)
- Ph.D. Physiologie, Université de Montréal (2002)
- Stages post-doctoraux
- Department of Neurology, Weill Medical College of Cornell University (2003-2006)
- Department of Pharmacology, University of Vermont (2006-2008)
Thèmes de recherche
- Pharmacologie cérébrovasculaire dans un organisme sain ou pathologique
- Mécanismes qui sous-tendent le couplage neurovasculaire cérébral
- Interactions entre les astrocytes et les vaisseaux sanguins
Approches techniques
- Pharmacologie cérébrovasculaire in vivo (fenêtre cranienne) et in vitro
(tranches de cerveau et vaisseaux isolés) - Mesure du débit sanguin cérébral in vivo à l’aide d’une sonde laser Doppler
- Microscopie multi-photon in vivo et in vitro
- Réactivité vasculaire sur des artères isolées
- Immunohistochimie
- Biologie moléculaire
Membre du laboratoire
- Clériston Farias Alves, étudiant à la maîtrise
- Mélissa Beauvillier, stagiaire
Publications
- Girouard H, Lessard A, Capone C, Milner TA, Iadecola C. The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic.Am J Physiol Heart Circ Physiol. 2008; 294(1): H156-H163. Girouard H, Park L, Anrather J, Zhou P, Iadecola C. Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II. ATVB. 2007; 27(2): 303-309
- Girouard H, Park L, Anrather J, Zhou P, Iadecola C. Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through nox-2-derived radicals. ATVB. 2006; 26(4):826-832
- Girouard H, Iadecola C. Invited Review: Neurovascular coupling in the normal brain and in hypertension, stroke and Alzheimer disease. J. Appl. Physiol. 2006; 100(1): 328-335
- Girouard H, de Champlain J. Acute and chronic effects of free radicals on alpha1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats. J. Hypertens. 2005; 23: 807-814
- Girouard H, Denault C, Chulak C, de Champlain J. Treatment by n-acetylcysteine and melatonin increases cardiac baroreflex and improves antioxidant reserve. Am. J. Hypertens. 2004; 17(10): 947954
- Girouard H, de Champlain J. Inhibitory effect of melatonin on alpha1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats. Am. J. Hypertens. 2004; 17(4): 339-346
- Girouard H, Chulak C, Lejossec M, De Champlain J. N-acetylcysteine treatment improves NO and alpha-adrenergic pathways in Mesenteric Artery of Spontaneously Hypertensive Rats. Am. J. Hypertens. 2003; 16(7): 577-584
- Girouard H, Chulak C, Lejossec M, Lamontagne D, De Champlain J. Chronic antioxidant treatment improves sympathetic functions and ß-adrenergic pathway in the spontaneously hypertensive rats. J Hypertens. 2003; 21(1): 179-188