| Title : | Professor, Department of Pharmacology, Faculty of Medicine
Director |
| Adress : | Institut de Recherches Cliniques de Montréal (IRCM) 110 Avenue des Pins ouest Montréal (Qc) H2W 1R7 |
| Office : | 5320 |
| Phone : | 514 987-5576 |
| Email : | schillp@ircm.qc.ca |
Formation
- Dipl. Chem. ETH (1967), Dr. Sc. tech. ETH (1971) École Polytechnique Fédérale Suisse à Zurich
- FRSC, Ottawa (1991)
- O.Q., Québec (1999)
- FAAAS, Washington, DC (2001)
Laboratory research activities
- Medicinal chemistry and molecular pharmacology of peptide hormones and neurotrnsmitters. Determination of structure-activity relationships of biologically active peptides using an interdisciplinary approach at the interface of chemistry and biology. A major focus is on opioid peptides as starting structures for the development of novel pharmacological tools and of analgesics devoid of the side effects of currently available opiate analgesics. Another research project concerns the development of a new class of mitochondria-targeted antioxidant peptides (SS-peptides) with therapeutic potential for the treatment of diseases associated with oxidative stress.
Techniques used
- Peptide chemistry
- Synthetic organic chemistry
- Medicinal chemistry techniques
- Pharmacological characterizations in vitro
- Structural (conformational) analyses (molecular modeling, receptor docking, NMRspectroscopy)
Present members
- Brian C. Wilkes, Ph.D. , chercheur associé
- Irena Berezowska, Ph.D., chercheuse associée
- Grazyna Weltrowska, M.Sc., assistante de recherche
- Nga N. Chung, B.Sc., assistante de recherche
- Carole Lemieux, B.Sc., assistante de recherche
- Thi M.-D. Nguyen, B.Sc., assistante de recherche
- Jinguo Ding, Ph.D., étudiant postdoctoral
- Steven Ballet, Ph.D., étudiant postdoctoral
Publications
- Berezowska, I., Chung, N.N., Lemieux, C., Wilkes, B.C. et SCHILLER, P.W. Dicarbaanalogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH2retain high opioid activity. J. Med. Chem. 50: 1414-1417, 2007.
- Audet, N., Galés, C., Archer-Lahlou, É., Valliers, M., SCHILLER, P.W., Bouvier, M. et Piñeyro, G. Bioluminescence resonance energy transfer assays reveal ligand-specificconformational changes within preformed signaling complexes containing δ-opioid receptors and heterotrimeric G proteins. J. Biol. Chem. 283: 15078-15088, 2008.
- Weltrowska, G., Nguyen, T.M.-D., Lemieux, C., Chung, N.N. et SCHILLER, P.W. Potent opioid agonists containing 4’-[N-((4’-phenyl)-phenethyl)carboxamido]phenyl-alanine (Bcp) in Place of Tyr1. Chemical Biology & Drug Design 72: 337-340, 2008.
- SCHILLER, P.W. Bi- or multifunctional opioid peptide drugs. LifeSci. doi:10.1016/j.lfs.2009.02.025.
- Berezowska, I., Chung, N.N., Lemieux, C., Wilkes, B.C. et SCHILLER, P.W. Agonist vs antagonist behavior of δ opioid peptides containing novel phenylalanine analogues in place of Tyr1. J. Med. Chem. 52: 6941-6945, 2009.