Mohit Kapoor


Title : Accredited member, Department of Pharmacology, Faculty of Medicine
Assistant Research Professor, Department of Medicine, University of Montreal
Canadian Arthritis Network Investigator
Canadian Scleroderma Research Group Investigator
Adress : Osteoarthritis Research Unit
Notre-Dame Hospital
University of Montreal Hospital Research Centre (CRCHUM)
1560 Sherbrooke Street East
Montreal, Quebec  H2L 4M1
Phone : 514 890-8000 ext. 25544
Email :


Arthritis, osteoarthritis, rheumatoid arthritis, inflammation, wound/tissue repair, fibrosis, scleroderma, cartilage growth and development, knockout mice, skin, cytokines, PPARgamma, prostaglandins, growth factors, cell/tissue culture, molecular biology.

Research Interests

My research employs multiple approaches including molecular, genetic and pharmacological tools to identify novel therapeutic targets and signalling pathways involved in cartilage growth and development and in the pathophysiology of osteoarthritis (OA) using genetically mice, animal models of OA and human OA specimens.

My other research interests include identification of mediators and signalling pathways involved in pro-inflammatory and pro-fibrotic responses associated with Scleroderma disease using animal models of fibrosis and human diseased and normal specimens.

Laboratory research activities

  • Understanding the biology of cartilage/bone growth and development.
  • Understanding the pathophysiology of osteoarthritis
  • Understanding the pathophysiology of scleroderma disease
  • Generation of genetically modified mice to understand the pathophysiology of
    Osteoarthritis or Scleroderma disease

Contribution of autophagy/stemness in osteoarthritis and scleroderma disease.

Present members

  • Dr. Yue Zhang: Postdoctoral Fellow
  • Dr. Parisa Ghassemi: MSc candidate
  • Faezeh Vasheghani: PhD Candidate
  • Gemma Perez: Research Assistant
  • Meryem Blati: Research Assistant


  • Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, St-Arnaud R, Taniguchi, N, Lotz M, Pelletier J-P, Martel-Pelletier J, Beier F and Kapoor M. Cartilage-specific deletion of PPARγ results in abnormal endochondral ossification and cartilage growth and development. Arthritis and Rheumatism (2011, Epub Ahead of print).
  • Kapoor M, Martel-Pelletier J, Lajeunesse D and Fahmi H and. Role of proinflammatory cytokines in the pathophysiology of Osteoarthritis. Nature Reviews Rheumatology, 2011, 7(1):33-42.
  • McCann MR, Monemdjou R, Ghassemi-Kakroodi, P, Fahmi H, Perez G, Liu S, Shi-wen X, Parapuram SK, Kojima F, Denton CP, Abraham DJ, Martel-Pelletier J, Crofford LJ, Leask A and Kapoor M. mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis. Arthritis Research and Therapy, 2011 25;13(1):R6.