Jean-Sébastien Joyal

Formation

• Postdoc Vascular biology and Ophthalmology, 2013
Harvard Medical School, Boston
• PhD Pharmacology, 2011
McGill University, McGill
• Fellowship Pediatric Cardiac Critical Care, 2010
Greet Ormond Street Hospital, London (UK)
• Fellowship Pediatric Critical Care, 2007
CHU Sainte-Justine, Montreal
• Residency Pediatrics, 2004
CHU Sainte-Justine, Montreal
• MD McGill University, 2000

Research Interests

Understanding the drivers of neovascularization is key to controlling many diseases. Vessels deliver oxygen and nutrients to match the energy demands of neurons. Although much is known about oxygen drivers of vessel growth, little is known about the neuronal energy signals that stimulate angiogenesis. We investigate relevant pathways to energy metabolism and angiogenesis in models of retinopathy and cancer.

Angiogenisis
Neuro-vascular guidance
Cell signalling and GPCR
Neuronal energy metabolism
Murine models of proliferative retinopathy and cancer

Present members

Marie-Josée Lacombe, M.Sc., Research Assistant

Noémie-Rose Harvey, M.D., Étudiante graduée à la Maitrise
Département de Pharmacologie, Université de Montréal

Yisha Chang, Étudiante graduée à la Maitrise
Département de Pharmacologie, Université de Montréal

Sarah Zahabi, Étudiante graduée à la Maitrise
Département de Pharmacologie, Université de Montréal

Publications

Sapieha P, et al. The succinate receptor GPR91 present on neurons, exerts a major role in retinal angiogenesis Nat Med 2008 Oct;14(10):1067-76.

Sapieha P, Joyal JS, et al. Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life. J Clin Invest. 2010 Sep 1;120(9):3022-32. Epub 2010 Sep 1.

Joyal JS, et al. Ischemic neurons prevent vascular regeneration of neural tissue by secreting Semaphorin 3A. Blood, 2011 Jun 2;117(22):6024-35. (Cover page and editorial)

Joyal JS, et al. Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and Semaphorin 3A. Acta Pediatrica 2012 Aug;101(8):819-26.

Chen J., Joyal JS, et al. Propranolol inhibition of β-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 May 17;53(6):2968-77.

Stahl A*, Joyal JS*, et al. SOCS3 is an endogenous inhibitor of pathologic angiogenesis. Blood, 2012 Oct 4;120(14):2925-9. (*Co-first author; Cover Page)

Binet F, et al. Neuronal Endoplasmic Reticulum Stress Leads to Degradation of Netrin-1 by IRE1α and Prevents Myeloid-cell Induced Neuro-vascular Regeneration. Cell Metabolism, 2013 Mar 5;17(3):353-71.

Rivera JC, et al. Microglia and Interleukin-1β in Ischemic Retinopathy Elicit Microvascular Degeneration Through Neuronal Semaphorin-3A. Arteriosclerosis, Thrombosis, and Vascular Biology 2013 Aug; 33(8):1881-91.

Chen J, et al. Neuronal Sirtuin1 mediates retinal vascular regeneration in retinopathy. Angiogenesis. Angiogenesis, 2013 Oct;16(4):985-92.