| Title : | Full professor, Department of pharmacology, Faculty of Medicine Accredited professor, Department of biochemistry, Faculty of Medicine Groupe d’étude des protéines membranaires (GÉPROM), regular member Groupe de recherche universitaire sur le médicament (GRUM), associate member |
| Adress : | Pavillon Roger-Gaudry P. O. Box 6128 – Downtown station Montréal (Québec) H3C 3J7 |
| Office : | S-457 |
| Phone : | 514 343-6111 #3085 |
| Email : | audrey.claing@umontreal.ca |
Formation
- B. Sc. Biochemistry (1990)
- M. Sc. Pharmacology (1992)
- Ph.D. Pharmacology, Université de Sherbrooke (1997)
- Postdoctoral fellowship, Department of Medicine and Biochemistry, Duke University, North Carolina, USA (2001)
Laboratory research activities
- Breast and colorectal cancer : Molecular mechanisms regulating cell migration, proliferation and invasion.
- Cardiovascular diseases : Elucidation of the proteins regulating migration and invasion of endothelial and vascular smooth muscle cells.
- G protein-coupled receptor signaling path ways
- Role of GRKs and Barrestin proteins in receptor function.
- Development de modulateur allostérique
- Role of small GTP binding proteins in receptor function.
- Molecular mechanisms regulating desensitization, internat
Techniques used
- Co-immunoprecipitations of cellular proteins
- Co-precipitation of purified proteins
- Confocal Microscopy
- Flow cytometry
- RNA interference
- Cell culture
- Protein purification
- Site-directed mutagenesis
- Western blot
- Biological assays for cell migration invasion, adhesion and proliferation
Present members
- Shirley Campbell, Ph.D.- coordonatrice de la recherche
- Eric Haines, étudiant au Ph.D.
- Ricardo Charles, étudiant au Ph.D.
- Danaë Tassy, étudiante au Ph.D.
- Sabrina Schlienger, étudiante au Ph.D.
- Mohamed Bourmoum, étudiant au Ph,D.
- Sara Ratni
- Alumni
- Sebastian Lewis-Saravalli, étudiant au M.Sc.
- Marie-Ève Poupart, M.Sc.
- Tanguy Houndolo, M.Sc.
- Derek Robertson, PDF
- Mathieu Cotton, Ph.D.
- Dario Bivona, M.Sc.
- Zeinab Daher, Ph.D.
- Pierre-Luc Boulay, Ph.D.
-
Present members
- Differential β-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs. Zimmerman B, Beautrait A, Aguila B, Charles R, Escher E, Claing A, Bouvier M, Laporte SA. Sci Signal. 2012 Apr 24;5(221):ra33.
- Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics. Bourguet CB, Goupil E, Tassy D, Hou X, Thouin E, Polyak F, Hébert TE, Claing A, Laporte SA, Chemtob S, Lubell WD. J Med Chem. 2011 Sep 8;54(17):6085-97. Epub 2011 Aug 9.
- ARF1 controls proliferation of breast cancer cells by regulating the retinoblastoma protein. Boulay PL, Schlienger S, Lewis-Saravalli S, Vitale N, Ferbeyre G, Claing A. Oncogene. 2011 Sep 8;30(36):3846-61. doi: 10.1038/onc.2011.100. Epub 2011 Apr 11.