Hélène Girouard

Formation

• B.Sc. en biologie, UQAM (1993)
• M. Sc. Biologie, UQAM (1996)
• Ph.D. Physiologie, Université de Montréal (2002)
• Stages post-doctoraux
  • Department of Neurology, Weill Medical College of Cornell University (2003-2006)
  • Department of Pharmacology, University of Vermont (2006-2008)

Thèmes de recherche

• Pharmacologie cérébrovasculaire dans un organisme sain ou pathologique
• Mécanismes qui sous-tendent le couplage neurovasculaire cérébral
• Interactions entre les astrocytes et les vaisseaux sanguins

Approches techniques

• Pharmacologie cérébrovasculaire in vivo (fenêtre cranienne) et in vitro
  (tranches de cerveau et vaisseaux isolés)
• Mesure du débit sanguin cérébral in vivo à l’aide d’une sonde laser Doppler
• Microscopie multi-photon in vivo et in vitro
• Réactivité vasculaire sur des artères isolées
• Immunohistochimie
• Biologie moléculaire

Membre du laboratoire

• Clériston Farias Alves, étudiant à la maîtrise
• Mélissa Beauvillier, stagiaire

Publications

• Girouard H, Lessard A, Capone C, Milner TA, Iadecola C. The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic.Am J Physiol Heart Circ Physiol. 2008; 294(1): H156-H163. Girouard H, Park L, Anrather J, Zhou P, Iadecola C. Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II. ATVB. 2007; 27(2): 303-309
• Girouard H, Park L, Anrather J, Zhou P, Iadecola C. Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through nox-2-derived radicals. ATVB. 2006; 26(4):826-832
• Girouard H, Iadecola C. Invited Review: Neurovascular coupling in the normal brain and in hypertension, stroke and Alzheimer disease. J. Appl. Physiol. 2006; 100(1): 328-335
• Girouard H, de Champlain J. Acute and chronic effects of free radicals on alpha1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats. J. Hypertens. 2005; 23: 807-814
• Girouard H, Denault C, Chulak C, de Champlain J. Treatment by n-acetylcysteine and melatonin increases cardiac baroreflex and improves antioxidant reserve. Am. J. Hypertens. 2004; 17(10): 947­954
• Girouard H, de Champlain J. Inhibitory effect of melatonin on alpha1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats. Am. J. Hypertens. 2004; 17(4): 339-346
• Girouard H, Chulak C, Lejossec M, De Champlain J. N-acetylcysteine treatment improves NO and alpha-adrenergic pathways in Mesenteric Artery of Spontaneously Hypertensive Rats. Am. J. Hypertens. 2003; 16(7): 577-584
• Girouard H, Chulak C, Lejossec M, Lamontagne D, De Champlain J. Chronic antioxidant treatment improves sympathetic functions and ß-adrenergic pathway in the spontaneously hypertensive rats. J Hypertens. 2003; 21(1): 179-188