Catherine Martel

Fonction des vaisseaux lymphatiques dans l'athérosclérose
Professeure sous octroi agrégé
Faculté de médecine - Département de médecine
Institut De Cardiologie De Mtl, local S5100
Professeure accréditée
Faculté de médecine - Département de pharmacologie et physiologie
514 376-3330, poste 2977

Disciplines

  • Cardiologie
  • Biologie cellulaire
  • Biologie moléculaire

Présence sur le Web

Expertise de recherche

Ses travaux postdoctoraux, cités dans de nombreux journaux et congrès internationaux, sont très certainement instigateurs de nouvelles avenues en recherche sur la santé cardio-vasculaire. Ils démontrent, qu’en condition d’hypercholestérolémie, le transport cellulaire et moléculaire par les vaisseaux lymphatiques est altéré: dans différents modèles d’athérosclérose, l’inefficacité du transport lymphatique résulte en l’accumulation de cholestérol dans les tissus périphériques, dont les artères. Les travaux actuels de ce nouveau laboratoire de recherche qu'elle a mis sur pied en 2014 visent à déterminer les rôles physiopathologiques du réseau lymphatiques dans l’initiation, la progression et la régression de l’athérosclérose. Des études fondamentales et translationelles (avec la collaboration des experts en recherche clinique) lui permettront  d’identifier les causes de ce transport lymphatique dysfonctionnel, et éventuellement de cibler des stratégies permettant de restaurer la fonction lymphatique dans les différents stades de la maladie athérothrombotique.

Biographie

Catherine Martel a obtenu son doctorat en 2009 de l’Université de Montréal et a  poursuivi sa formation postdoctorale au Mount Sinai School of Medicine de New York, puis à la Washington University School of Medicine à St Louis, Missouri, durant laquelle elle a entre autre obtenu le prix du Junior Investigator Award for Women de l'American Heart Association (ATVB). 

Affiliations de recherche UdeM

Pour en savoir plus

Prix et distinctions

2018-2019   Prix Martial G. Bourassa, Outstanding scientist < 45 years-old (Montreal Heart Institute, Quebec, Canada)

2018-2019   Société Québécoise d’Hypertension Artérielle (SQHA), New Investigator Award (Quebec, Canada)

2016-2017   Fondation Jacques-de Champlain / Heart & Stroke Fondation, New Investigator Award

2016           Banting Research Foundation, Discovery Award

2013-2014   Montreal Heart Institute Foundation, Bourse Norman D. Hébert

2013           American Heart Association, Best of American Heart Association’s Specialty Conferences

2013           American Heart Association, Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) Council, Travel Award for Young Investigators

2012           Washington University School of Medicine in St Louis (MO), First Prize – Postdoctoral trainee/Resident/Fellow Research Award

2012           American Heart Association, Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) Council, Junior Investigator Award for Women 2012

2011           Canadian Institutes of Health Research, Committee: Institute of Nutrition, Metabolism and Diabetes, Travel Award

2011           Société des Sciences Vasculaires du Québec (SSVQ), Top-ranked presentation

2011           Gordon Research Conference on Atherosclerosis, Top-ranked presentation

2006-2009   Canadian Institutes of Health Research, Doctoral Research Award (Montreal, Canada)

2007-2008   French government (INSERM) and the Quebec government (FRQS), Doctoral Research Scholarship (Paris, France)

 

 

Organisation d’événements

1. Comités d'examen par les pairs

  • Heart and Stroke Foundation of Canada, Sub-panel VI, Thrombosis / lipid and lipoproteins / fundamental nutrition research (2016 - present)
  • Non-resident expert, The French National Research Agency (ANR), Projet de recherche collaborative, Committee number CE14 (2017)
  • Fonds de recherche du Québec — Santé, Bourse à la maîtrise (2016 - present)
  • Canadian Institutes of Health Research – Postdoctoral Fellowships Program (2016 - 2017)
  • Programme Sc. Biomédicales, Université de Montréal – Bourse aux études graduées (2015 - present)
  • Fondation de l’Institut de Cardiologie de Montréal, Bourse d’excellence, études graduées (2016 - present)

2. Activités de gestion / Participation à des activités sans but lucratif

  • Board of Directors, Canadian Society of Arteriosclerosis, Thrombosis, and Vascular Biology (2016 - present)
  • President - Montreal Heart Institute Animal Ethics Committee (2017 - present)
  • Member - Montreal Heart Institute Animal Ethics Committee (2015 - present)
  • Future Science Early Career Research Award judging panel (2017 - present)
  • Early Career Committee of the ATVB Council  of the AHA (2013 - 2017)

3. Organisation d'événements

  • Co-Chair of the 2020 CSATVB & CLD joint Annual Meeting, Québec
  • Chair of the 2019 Spring HDL Workshop, Boston
  • Moderator, 2018 American Heart Association Scientific Sessions – Meaningful Translational Research: Mouse to Human, Chicago
  • Chair of the 2018 Spring HDL Workshop, San Francisco
  • President of the 2016 Montreal Heart Institute Research Day, Montreal
  • Workshop co-chair/speaker, ATVB Early Career Training Sessions (2013 - 2017)
  • Scientific judge at the 2016 Congress of the Quebec Society of Vascular Sciences, Montreal
  • Scientific judge at the Montreal Heart Institute Research Day, Montreal (2014-2016)
  • Organizing committee member of the 2015 Montreal Heart Institute Research Day, Montreal

4. Rapporteur scientifique pour des revues et des conférences internationales

  • Circulation Research
  • Cardiovascular Research
  • Scientific Reports
  • Canadian Journal of Cardiology
  • Journal of the American College of Cardiology
  • Clinical and Translational Medicine
  • Journal of Clinical & Cellular Immunology
  • Trends in Endocrinology and Metabolism
  • Journal of Thoracic Disease
  • American Heart Association (AHA) Scientific Sessions (Abstract reviewer)
  • Future Science Open Access

5. Activités d'éditions

  • Young Ambassador, Future Science OA (2015 - 2016)
  • Member of Editorial Board, Future Science OA (2016 - present)
  • Social Media Editor, Future Science OA (2016 - present)

Publications

Publications sélectionnées

  1. S. Pasquin, S. Chehboun, A. Dejda, Y. Meliani, V. Savin, G. Warner, R. Bosse, A. Tormo, G. Mayer, M. Sharma, P. Sapieha, C. Martel, J. Gauchat. Cardiotrophin-like cytokine, a lipocytokine? Scientific Reports. 2018 Mar 5;8(1):3990
  2. A. Milasan, G. Jean, F. Dallaire, J. Tardif, Y. Merhi, M. Sorci-Thomas, C. Martel. Apolipoprotein A-I modulates atherosclerosis through lymphatic vessel-dependent mechanisms in mice. Journal of the American Heart Association. 2017 September. https://doi.org/10.1161/JAHA.117.006892
  3. S. Cointe, E. Rhéaume, C. Martel, O. Blanc-Brude, É. Dubé, F. Sabatier, F. Dignat-George, J. Tardif, A. Bonnefoy. The thrombospondin-1-derived peptide RFYVVMWK improves the adhesive phenotype of CD34+ cells from atherosclerotic patients with type II diabetes. Cell Transplantation. 2016 October. https://doi.org/10.3727/096368916X693329
  4. C. Martel. Life as an early career researcher. Future Science OA, 2016 Feb 12;2(1):FSO108. doi: 10.4155/fsoa-2016-0011.
  5. A. Milasan, N. Tessandier, S. Tan, A. Brisson, E. Boilard, C. Martel. Extracellular vesicles are present in mouse lymph and their level differs in atherosclerosis. Journal of Extracellular Vesicles 2016, 5: 31427.
  6. H. Zhang, T. Vallim, C. Martel. Translational and therapeutic approaches to the understanding and treatment of dyslipidemia. Arterioscler Thromb Vasc Biol. 2016  36: e56-e61
  7. A. Milasan, F. Dallaire, G. Mayer, C. Martel. (2016) Effects of LDL Receptor Modulation on Lymphatic Function. Scientific Reports. 2016 Jun 9;6:27862. doi: 10.1038/srep27862.
  8. A Milasan, J Ledoux, C Martel. Lymphatic network in atherosclerosis: the underestimated path. Future Science OA, 2015 Aug (6):1-10.
  9. C.N. Manning, C. Martel, S. Sakiyama-Elbert, M.J. Silva, G.J. Randolph, R.H. Gelberman, S. Thomopoulos. Adipose-derived mesenchymal stromal cells modulate tendon fibroblast responses to macrophage-induced inflammation. Stem Cell Research & Therapy. 2015 Apr 16;6(1):74.
  10. C. Martel, J. Yao, C.H. Huang, J. Zou, G.J. Randolph , L.V. Wang. Photoacoustic lymphatic imaging with high spatial-temporal resolution. Journal of Biomed Optic. 2014 19(11), 116009. (Corresponding author).
  11. H. Zhang, R.E. Temel, C. Martel. Cholesterol and lipoprotein metabolism. Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1791-4.
  12. R. Duivenvoorden, J. Tang, D.P. Cormode, A.J. Mieszawska, D. Izquierdo-Garcia, C. Ozcan, M.J. Otten, N. Zaidi, M.E. Lobatto, S.M. van Rijs, B. Priem, E. L. Kuan, C. Martel, B. Hewing, H. Sager, M. Nahrendorf, G. J. Randolph, E.S.G. Stroes, V. Fuster, E.A. Fisher, Z.A. Fayad, W.J.M. Mulder. A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation. Nat Commun. 2014 Jan 20;5:3065.
  13. S. Ivanov, C. Martel. Does lymphatic growth rely on immune cell function? OA Immunology 2013 Sep 01;1(1)8.
  14. C. Martel, G.J. Randolph. Atherosclerosis and transit of HDL through the lymphatic vasculature. Curr Atheroscler Rep. 2013 Sep;15(9):354. (Invited review; Special feature in www.MDLinx.com) (Corresponding author).
  15. A.M. Platt, J.M. Rutkowski, C. Martel, E.L. Kuan, S. Ivanov, M. A. Swartz, G. J. Randolph. Scarce lymphatic capillaries can be sufficient to support normal murine dendritic cell mobilization. J Immunol. 2013 May 1;190(9):4608-20.
  16. C. Martel, W. Li, B. Fulp, A.M. Platt, E.L. Gautier, M. Westerterp, R. Bittman, A.R. Tall, S.H. Chen, M.J. Thomas, D. Kreisel, M.A. Swartz, M.G. Sorci-Thomas, G.J. Randolph. Macrophage reverse cholesterol transport in mice relies on the lymphatic vasculature. J Clin Invest. 2013; 123(4):1571–1579. (Selected to be featured in “JCI Impact” http://www.jci.org/kiosk/impact)
  17. J. Yao, C.H. Huang, C. Martel, K.I. Maslov, L. Wang, J.M. Yang, L. Gao, G.J. Randolph, J. Zou, L.V. Wang. Water-Immersible MEMS Scanning Mirror Designed for Wide-field Fast-scanning Photoacoustic Microscopy. Conference Proceedings, Proc. SPIE 2013; 8581.
  18. P. Theroux, C. Martel, A. Bonnefoy. Blocking the Terminal Complement Complex: Mismatch and Misconception. Am Heart Journal, 2012 Dec;164(6):e21.
  19. C. Martel, C.B. Granger, M. Ghitescu, A. Stebbins, A. Fortier, P.W. Armstrong, A. Bonnefoy, P. Theroux. Pexelizumab fails to inhibit assembly of the terminal complement complex in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Insight from a substudy of the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Am Heart Journal, 2012 Jul;164(1):43-51.
  20. E. Dumas, C. Martel, P.E. Neagoe, A. Bonnefoy, M.G. Sirois. Angiopoietin-1 but not angiopoietin-2 promotes neutrophil viability: Role of interleukin-8 and platelet-activating factor. Biochim Biophys Acta – Molecular Cell Research. 2012 Feb;1823(2):358-67.
  21. C. Martel, S. Cointe, P. Maurice, S. Matar, M. Ghitescu, P. Théroux, A. Bonnefoy. Requirements for membrane attack complex formation and anaphylatoxins binding on collagen-activated platelets. PLoS ONE 2011 Apr 15;6(4):e18812.
  22. B. Marcheix, M. Carrier, C. Martel, M. Cossette, M. Pellerin, D. Bouchard, LP Perrault. Effect of pericardial blood processing on postoperative inflammation and the complement pathways. Ann Thorac Surg. 2008 Feb;85(2):530-5.
  23. P. Théroux, C. Martel. Complement activation in acute coronary syndromes. Can J Cardiol. 2006 Feb;22 Suppl B:18B-24B