Angelo Calderone

Pour comprendre les mécanismes cellulaires et moléculaires dans le développement de l'hypertrophie cardiaque et la progression subséquente de l'insuffisance cardiaque.

B.Sc. Biochimie , McGill University (1986)

Ph.D. Physiologie , Université de Montréal, (1992)

Études post-doctoral, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA (1995)

Bergeron A, Hertig V, Villeneuve L, Chauvette V, El-Hamamsy I, Calderone A. The ascending aorta of male hypertensive bicuspid aortic valve patients preferentially associated with a cellular aneurysmal phenotype. Physiological Reports, 2022;10:e15251. doi: 10.14814/phy2.15251.

Bergeron A, Hertig V, Villeneuve L, Sirois MG, Demers P,  El-Hamamsy I, Calderone A. Structural dysregulation of the pulmonary autograft was associated with a greater density of p16INK4A-vascular smooth muscle cells. Cardiovascular Pathology, 2023 Dec 15;107512. doi: 10.1016/j.carpath.2022.107512.

 Kebbe M, Naud P, Ines A, Gagnon E, McCall A, Villeneuve L, LeBlanc CA, Nguyen QT, Calderone A. Distinct Protein Kinase C isoforms drive the cell cycle re-entry of two separate populations of neonatal rat ventricular cardiomyocytes. American J of Physiology; Cell Physiology, 2023, Aug 1;325(2): C406-C419.

Al-Katat A, Bergeron A, Parent L, Lorenzini M, Fiset C, Calderone A. Rapamycin treatment unmasks a sex-specific pattern of scar expansion of the infarcted rat heart; relationship between mTOR and KATP channel. IUBMB Life, 2023, Sep;75(9): 717-731

Hertig V, Villeneuve L, Calderone A. Nestin identifies a subpopulation of rat ventricular fibroblasts and participates in cell migration. Am J Physiol Cell Physiol. 2023, Aug 1;325(2): C496-C508.

Al-Katat A, Boudreau L, Gagnon E, Assous I, Villeneuve L, Leblanc CA, Bergeron A, Sirois MG, El-Hamamsy I, Calderone A. Greater TIMP-1 protein levels and neointimal formation represent sex-dependent cellular events limiting aortic vessel expansion in female rats. IUBMB Life. 2024 Dec;76(12):1356-1376.