Christian Beauséjour

Formation

• B. Sc. au Département de biochimie à l’Université de Montréal (1995)
• Ph. D. au Département de pharmacologie et physiologie à l’Université de Montréal (2001)
• Postdoc :  Lawrence Berkeley National Laboratory (2001-2003)
• Postdoc :  Berlex Biosciences (2003-2004)
• Scientist : Sangamo Biosciences (2004-2005)

Membres du laboratoire

• Oanh Le, assistante de recherche
• Basma Benabdallah, associée de recherche
• Damien Maggiorani, postdoctorant
• Joshua Dulong, postdoctorant
• Marie-Lyn Goyer, étudiante au doctorat
• Monica Liliane Cruz Barrera, étudiante au doctorat
• Paola Saavedra, étudiante à la maitrise

Thèmes

• Le rôle de la sénescence cellulaire dans le renouvellement tissulaire et le cancer
• Thérapies cellulaires utilisant les cellules souches pluripotentes induites (iPSC)

Publications choisies

• Gaël Moquin-Beaudry, Basma Benabdallah, Damien Maggiorani, Oanh Le, Yuanyi Li, Chloé Colas, Claudia Raggi, Benjamin Ellezam, Marie McCallum, Dorothée Dal Soglio, Jean V. Guimond, Massimiliano Paganelli, Elie Haddad, Christian Beauséjour. Development of novel preclinical humanized mouse models in immuno-oncology. Submitted
• Claudia Raggi, Marie-Agnès M’Callum, Quang Toan Pham, Silvia Selleri, Radu Alexandru Paun, Nissan Baratang, Chenicka Lyn Mangahas, Basma Benabdallah, Dorothée Dal Soglio,Yves Théoret, Robert Schwartz, Christian Beauséjour, Elie Haddad, Massimiliano Paganelli. Allogeneic pluripotent stem cell-derived encapsulated liver tissue: safe and effective treatment of acute liver failure without the need of Submitted
• Kerstin Killer, Oanh Le and Christian Beausejour. The intracerebroventricular injection of murine mesenchymal stromal cells engineered to secrete epidermal growth factor does not prevent loss of neurogenesis in irradiated mice. Radiation Research 2021.
• Sergio Crespo-Garcia; Pamela R Tsuruda; Agnieszka Dejda; Rathi Ryan; Frederik Fournier; Shawnta Y Chaney; Surabhi R Rao; Frederique Pilon; Taner Dogan; Gael Cagnon; Priyanka Patel; Manuel Buscarlet; Sonali Dasgupta; Gabrielle Girouard; Robert O’brien; Rachel Juneau; Vera Guber; Alexandre Dubrac; Christian Beausejour; Scott Armstrong; Frederick A Mallette; Christopher B Yohn; Jean-Sebastien Joyal; Dan Marquess; Pedro Beltran; Przemyslaw Sapieha. Pathological angiogenesis in retinopathy engages p16INK4A and is amenable to therapeutic elimination through BCL-xL inhibition Cell Metabolism 2021.
• Basma Benabdallah, Cynthia Désaulniers-Langevin, Marie-Lyn Goyer, Chloé Colas, Chantale Maltais, Yuanyi Li, Jean V Guimont, Jacques P Tremblay, Elie Haddad and Christian Beauséjour. Immune tolerance of human induced pluripotent stem cell-derived myogenic progenitor cells in humanized mice. Stem Cells Translational Medicine 2020
• Amr Omer, Monica Cruz Barrera, Xian Lian, Sergio Di Marco, Christian Beausejour, and Imed-Eddine Gallouzi « The stress granule protein G3BP1 controls the senescence-associated secretome and its impact on cancer progression ». Nature Communication 2020.
• Basma Benabdallah, Cynthia Désaulniers-Langevin, Yuanyi Li, Jean V. Guimont, Elie Haddad and Christian Beauséjour. Immune rejection of human induced pluripotent stem cells is mediated by NK cells in humanized mice. Frontiers in Immunology 2019
• Gael Moquin-Beaudry, Chloé Colas, Yuanyi Li, René Bazin, Jean V Guimont, Elie Haddad and Christian Beauséjour. The tumor immune response is not compromised by mesenchymal stromal cells in humanized mice. Journal of Immunology 2019
• Elodie Da Costa, Gregory Armaos, Gabrielle McInnes, Annie Beaudry, Gaël Moquin-Beaudry, Virginie Bertrand-Lehouillier, Maxime Caron, Chantal Richer, Pascal St-Onge, Jeffrey Johnson, Nevan Krogan, Yuka Sai, Michael Downey, Moutih Rafei, Meaghan Boileau, Kolja Eppert, Ema Florez-Dias, Andre Haman, trang hoang, Daniel Sinnett, Christian Beauséjour, Serge McGraw, and Noël Raynal. Targeting MYC Overexpressing Leukemia with Cardiac Glycoside Proscillaridin Through Downregulation of Histone Acetyltransferases. J Exp Clin Res. 2019
• Palacio L, Espinosa A, Goyer Marie-Lyn, Maggiorani Damien, Villeneuve N, Bourbonnais S, Moquin-Beaudry G, Le O, Demaria M^, Decaluwe H and Beauséjour C. IR-induced senescence in the splenic environment interferes with murine immune cells functions. Aging Cell. 2019
• Marco De Cecco, Takahiro Ito, Anna P. Petrashen, Amy E. Elias, Nicholas J. Skvir, Steven W. Criscione, Alberto Caligiana, Greta Brocculi, Emily M. Adney, Jef D. Boeke, Oanh Le, Christian Beauséjour, Jayakrishna Ambati, Kameshwari Ambati, Matthew Simon, Andrei Seluanov, Vera Gorbunova, P. Eline Slagboom, Stephen L. Helfand, Nicola Neretti, John M. Sedivy. LINE-1 elements are derepressed in senescent cells and elicit a chronic Type-I Interferon response. Nature
• Le O, Palacio L, Bernier G, Batinic-Haberle I, Hickson G, Beausejour CM. INK4a/ARF expression impairs neurogenesis in the brain of irradiated mice. Stem Cell Reports 2018, April 26.
• Galbiati A, Beausejour C and d’Adda di Fagnagna F. A novel single-cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues. Aging Cell 2017, Apr;16(2):422-427
• Palacio L, Le O, Krishna V, Sharpless NE and Beauséjour CM. Sustained p16^INK4a expression is required to prevent IR-induced tumorigenesis in mice. Oncogene 2016
• Selleri S, Bifsha P, Civini S, Pacelli C, Dieng MM, Lemieux W,Jin P, Bazin R, Patey N, Marincola FM, Moldovan F, Zaouter C, Trudeau LE, Benabdhalla B, Louis I, Beauséjour C, Stroncek D, Le Deist F and Haddad E. Human mesenchymal stromal cell-secreted lactate induces M2- macrophage differentiation by metabolic reprogramming. Oncotarget 2016, 24;7(21):30193-210