| Titre: |
Professeur associé, Département de pharmacologie et physiologie, Faculté de médecine, Université de Montréal Professeur titulaire, Département de chimie, Université du Québec à Montréal Chaire de Recherche en Prévention et Traitement du Cancer, directeur Groupe d’étude des protéines membranaires (GÉPROM), membre associé Réseau de Thérapie Cellulaire et Tissulaire ThéCELL, membre Centre d’Excellence en Recherche sur les Maladies Orphelines, membre Coalition Priorité Cancer au Québec, membre |
| Adresse: | Université du Québec à Montréal Département de Chimie 2101 Jeanne-Mance Montréal (Québec) H3C 3P8 |
| Local: | Bureau CB-4150 |
| Téléphone: | 514 987-3000, poste 7610 (Bur) 514 987-3000, poste 6697 (Lab) |
| Courriel: | annabi.borhane@uqam.ca |
Formation
- B. Sc. Biochimie, Université de Montréal (1990)
- M. Sc. Biochimie, Université de Montréal (1994)
- Ph. D. Biochimie, Université de Montréal (1997)
- Stage post-doctoral, National Institute of Child Health and Human Development, Bethesda, USA (1998)
- Stage post-doctoral, Centre de Recherche – Hopital Sainte-Justine, Montréal, Canada (2001)
Membres du laboratoire
- Dr Amira Ouanouki, associée de recherche
- Dr Bogdan Alexandru Danalache, associé de recherche
- Dr Khalil Abdelbaqi, associé de recherche
- Véronique Lullier, assistante de recherche
- Alain Zgheib, assistant de recherche
- Narjara Gonzalez Suarez, étudiante Ph.D.
- Sima Torabidastgerdooei, étudiante Ph.D.
- Meriem Benhamida, étudiante M.Sc.
- Celia Kassouri, étudiante M.Sc.
- Sara Aouissi, étudiante M.Sc.
- Marie-Eve Roy, étudiante M.Sc.
- Loraine Gresseau, étudiante M.Sc.
- Sahily Rodriguez Torres, étudiante M.Sc.
Alumni
- Dr Mayya Meriane
- Dr Amel Guezguez
- Dr Reshu Gupta
- Dr Chirine Toufaily
- Dr David Beauchemin
- Dr Ana Carolina B. M. Martin
- Dr Khadidja Haidara
- Dr Sylvie Lamy
- Dr Michel Demeule
- Dr Cyndia Charfi
- Jean-Christophe Currie
- Anissa Belkaid
- Simon Fortier
- Simon Lord-Dufour
- Martha Maria Cajina Herrera
- Carl Laflamme
- Asmaa Sina
- Elizabeth Tahanian
- Sébastien Proulx-Bonneau
- Éric Vaillancourt-Jean
- Naoufal Akla
- Rima Chokor
- Alain Zgheib
- Paula Liana Moldovan
- Michel Desjarlais
- Aroua Ben Saad
- Hana Benenemissi
- Pascale Gagné
- Samuel Burke-Nanni
- Samuel Sheehy
- Bayader Annabi
- Amélie Vézina
- Jonathan Pratt
- Laurence Lejeune
- Evelyne Muhire
- Clémence Bensiali-Haddaud
- Djahida Djerir
- Amira Ouanouki
- Wendenmi Tiziana Manuella Dao
- Marbelis Francisco Fernandez
- Audrey-Ann Sicard
- Samaneh Kamyabiazar
- Souad Djediai
Publications récentes
Charfi C, Demeule M, Currie JC, Larocque A, Zgheib A, Danalache BA, Ouanouki A, Béliveau R, Marsolais C, ANNABI B (2021) New peptide-drug conjugates for precise targeting of SORT1-mediated vasculogenic mimicry in the tumor microenvironment of TNBC-derived MDA-MB-231 breast and ovarian ES-2 clear cell carcinoma cells. Frontiers in Oncology 11:760787
Demeule M, Charfi C, Currie JC, Larocque A, Zgheib A, Kozelko S, Béliveau R, Marsolais C, ANNABI B (2021) TH1902, a new docetaxel-peptide conjugate for the treatment of sortilin-positive triple-negative breast cancer. Cancer Science 12(10):4317-4334
Uthamacumaran A, Gonzalez Suarez N, Baniré Diallo A, ANNABI B. (2021) Computational Methods for Structure-to-Function Analysis of Diet-Derived Catechins-Mediated Targeting of In Vitro Vasculogenic Mimicry. Cancer Informatics 20:1-8
González Suárez N, Rodriguez Torres S, Ouanouki A, El Cheikh-Hussein L, ANNABI B (2021) EGCG inhibits adipose-derived mesenchymal stem cells differentiation into adipocytes and prevents a STAT3-mediated paracrine oncogenic control of triple-negative breast cancer cell invasive phenotype. Molecules 26(6):1506
Sicard AA, Gonzalez Suarez N, Cappadocia L, ANNABI B (2021) Functional targeting of the TGF-βR1 kinase domain and downstream signaling: A role for the galloyl moiety of green tea-derived catechins in ES-2 ovarian clear cell carcinoma. Journal of Nutritional Biochemistry 87:108518
Sicard AA, Dao T, Gonzalez Suarez N, ANNABI B (2021) Diet-derived gallated catechins prevent TGF-β-mediated epithelial-mesenchymal transition, cell migration and vasculogenic mimicry in chemosensitive ES-2 ovarian cancer cells. Nutrition and Cancer 73(1):169-180
Abusarah J, Khodayarian F, El-Hachem N, Cui Y, Olivier M, Balood M, Roversi K, Talbot S, Bikorimana JP, Chen J, Jolicoeur M, Ramet L, Kamyabiazar S, ANNABI B, Robert CF, Pelletier J, El-Khadiry A, Shammaa R, Rafei M. (2021) Engineering a potent cancer vaccine using immunoproteasome-expressing mesenchymal stromal cells. Cell Reports Medicine (in press)
AbuSarah J., Cui Y., EL-Hachem N., El-Kadiry AE, Martel IH, Wurtele H, Beaudry A, Raynal N, Robert F, Pelletier J, Jankovic M, Mercier F, Kamyabiazar S, ANNABI B., Rafei M. (2021) TACIMA-218: A novel pro-oxidant agent exhibiting selective anti-tumoral activity. Molecular Cancer Therapeutics 20(1):37-49
Dao T, Salahuddin S, Charfi C, Sicard AA, Jenabian MA, ANNABI B (2020) Impact of diet-derived polyphenol EGCG on NTSR3/Sortilin expression and function upon HL-60 promyelocytic cells acquisition of a macrophage-like phenotype. PharmaNutrition 12:100191
Francisco Fernandez M, Charfi C, Piloto-Ferrer J, Gonzales ML, Lamy S, ANNABI B (2019) Impact of a Xanthium strumarium L extract on targeting of ovarian cancer cell resistance phenotype. Evidence-Based Complementary and Alternative Medicine 2019:1-13
Desjarlais M, ANNABI B (2019) Dual functions of ARP101 in targeting membrane type-1 matrix metalloproteinase : Impact on brain cancer cell invasion and autophagy signaling. Chemical Biology & Drug Design 93(3):272-282