Borhane Annabi


Titre:

Professeur associé, Département de pharmacologie et physiologie, Faculté de médecine, Université de Montréal

Professeur titulaire, Département de chimie, Université du Québec à Montréal

Chaire de Recherche en Prévention et Traitement du Cancer, directeur

Groupe d’étude des protéines membranaires (GÉPROM), membre associé

Réseau de Thérapie Cellulaire et Tissulaire ThéCELL, membre

Centre d’Excellence en Recherche sur les Maladies Orphelines, membre

Coalition Priorité Cancer au Québec, membre
Adresse: Université du Québec à Montréal
Département de Chimie
2101 Jeanne-Mance
Montréal (Québec) H3C 3P8
Local: Bureau CB-4150
Téléphone: 514 987-3000, poste 7610 (Bur)
514 987-3000, poste 6697 (Lab)
Courriel: annabi.borhane@uqam.ca

Formation

  • B. Sc. Biochimie, Université de Montréal (1990)
  • M. Sc. Biochimie, Université de Montréal (1994)
  • Ph. D. Biochimie, Université de Montréal (1997)
  • Stage post-doctoral, National Institute of Child Health and Human Development, Bethesda, USA (1998)
  • Stage post-doctoral, Centre de Recherche – Hopital Sainte-Justine, Montréal, Canada (2001)

Membres du laboratoire

  • Dre Isabelle Cousineau, associée de recherche
  • Dre Maria de la Cruz Dominguez Punaro, associée de recherche
  • Dr Daniil Petrenyov, associé de recherche
  • Dr Bogdan Alexandru Danalache, associé de recherche
  • Dr Naoufal Akla, Chercheur postdoctoral
  • Alain Zgheib, assistant de recherche
  • Narjara Gonzalez Suarez, étudiante Ph.D.
  • Sima Torabidastgerdooei, étudiante Ph.D.
  • Meriem Benhamida, étudiante M.Sc.
  • Marie-Eve Roy, étudiante M.Sc.
  • Kaenon Prisca-Désiré Gnao, Étudiante M.Sc.
  • Lydia Zerrouki, Étudiante M.Sc.

Alumni

  • Dr Mayya Meriane
  • Dr Amel Guezguez
  • Dr Reshu Gupta
  • Dr Chirine Toufaily
  • Dr David Beauchemin
  • Dr Ana Carolina B. M. Martin
  • Dr Khadidja Haidara
  • Dr Sylvie Lamy
  • Dr Michel Demeule
  • Dr Cyndia Charfi
  • Dr Amira Ouanouki
  • Dr Khalil Abdelbaqi
  • Jean-Christophe Currie
  • Anissa Belkaid
  • Simon Fortier
  • Simon Lord-Dufour
  • Martha Maria Cajina Herrera
  • Carl Laflamme
  • Asmaa Sina
  • Elizabeth Tahanian
  • Sébastien Proulx-Bonneau
  • Éric Vaillancourt-Jean
  • Naoufal Akla
  • Rima Chokor
  • Alain Zgheib
  • Paula Liana Moldovan
  • Michel Desjarlais
  • Aroua Ben Saad
  • Hana Benenemissi
  • Pascale Gagné
  • Samuel Burke-Nanni
  • Samuel Sheehy
  • Bayader Annabi
  • Amélie Vézina
  • Jonathan Pratt
  • Laurence Lejeune
  • Evelyne Muhire
  • Clémence Bensiali-Haddaud
  • Djahida Djerir
  • Amira Ouanouki
  • Wendenmi Tiziana Manuella Dao
  • Marbelis Francisco Fernandez
  • Audrey-Ann Sicard
  • Samaneh Kamyabiazar
  • Souad Djediai
  • Véronique Lullier
  • Virginie Desse
  • Celia Kassouri
  • Loraine Gresseau
  • Sahily Rodriguez Torres

Publications récentes

Kassouri C, Rodriguez Torres S, Gonzalez Suarez N, Duhamel S, ANNABI B. EGCG Prevents the Transcriptional Reprogramming of an Inflammatory and Immune-Suppressive Molecular Signature in Macrophage-like Differentiated Human HL60 Promyelocytic Leukemia Cells. Cancers (Basel). 2022 Oct 16;14(20):5065

Demeule M, Charfi C, Currie JC, Zgheib A, Danalache BA, Béliveau R, Marsolais C, ANNABI B. The TH1902 Docetaxel Peptide-Drug Conjugate Inhibits Xenografts Growth of Human SORT1-Positive Ovarian and Triple-Negative Breast Cancer Stem-like Cells. Pharmaceutics. 2022 Sep 9;14(9):1910.

Currie JC, Demeule M, Charfi C, Zgheib A, Larocque A, Danalache BA, Ouanouki A, Béliveau R, Marsolais C, ANNABI B. The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers. Cancers (Basel). 2022 Apr 8;14(8):1877.

Gonzalez Suarez N, Fernandez-Marrero Y, Torabidastgerdooei S, ANNABI B. EGCG Prevents the Onset of an Inflammatory and Cancer-Associated Adipocyte-like Phenotype in Adipose-Derived Mesenchymal Stem/Stromal Cells in Response to the Triple-Negative Breast Cancer Secretome. Nutrients. 2022 Mar 5;14(5):1099.

Djediai S, Gonzalez Suarez N, El Cheikh-Hussein L, Rodriguez Torres S, Gresseau L, Dhayne S, Joly-Lopez Z, ANNABI B. MT1-MMP Cooperates with TGF-β Receptor-Mediated Signaling to Trigger SNAIL and Induce Epithelial-to-Mesenchymal-like Transition in U87 Glioblastoma Cells. Int J Mol Sci. 2021 Nov 30;22(23):13006.

Charfi C, Demeule M, Currie JC, Larocque A, Zgheib A, Danalache BA, Ouanouki A, Béliveau R, Marsolais C, ANNABI B (2021) New peptide-drug conjugates for precise targeting of SORT1-mediated vasculogenic mimicry in the tumor microenvironment of TNBC-derived MDA-MB-231 breast and ovarian ES-2 clear cell carcinoma cells.  Frontiers in Oncology  11:760787

Demeule M, Charfi C, Currie JC, Larocque A, Zgheib A, Kozelko S, Béliveau R, Marsolais C, ANNABI B (2021) TH1902, a new docetaxel-peptide conjugate for the treatment of sortilin-positive triple-negative breast cancer.  Cancer Science  12(10):4317-4334

Uthamacumaran A, Gonzalez Suarez N, Baniré Diallo A, ANNABI B. (2021) Computational Methods for Structure-to-Function Analysis of Diet-Derived Catechins-Mediated Targeting of In Vitro Vasculogenic Mimicry.  Cancer Informatics  20:1-8

González Suárez N, Rodriguez Torres S, Ouanouki A, El Cheikh-Hussein L, ANNABI B (2021) EGCG inhibits adipose-derived mesenchymal stem cells differentiation into adipocytes and prevents a STAT3-mediated paracrine oncogenic control of triple-negative breast cancer cell invasive phenotype.  Molecules  26(6):1506

Sicard AA, Gonzalez Suarez N, Cappadocia L, ANNABI B (2021) Functional targeting of the TGF-βR1 kinase domain and downstream signaling: A role for the galloyl moiety of green tea-derived catechins in ES-2 ovarian clear cell carcinoma.  Journal of Nutritional Biochemistry  87:108518

Sicard AA, Dao T, Gonzalez Suarez N, ANNABI B (2021) Diet-derived gallated catechins prevent TGF-β-mediated epithelial-mesenchymal transition, cell migration and vasculogenic mimicry in chemosensitive ES-2 ovarian cancer cells.  Nutrition and Cancer  73(1):169-180

Abusarah J, Khodayarian F, El-Hachem N, Salame N, Olivier M, Balood M, Roversi K, Talbot S, Bikorimana JP, Chen J, Jolicoeur M, Trudeau LE, Kamyabiazar S, ANNABI B, Robert F, Pelletier J, El-Kadiry AE, Shammaa R, Rafei M. Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice. Cell Rep Med. 2021 Dec 21;2(12):100455.

Mélin L, Abdullayev S, Fnaiche A, Vu V, González Suárez N, Zeng H, Szewczyk MM, Li F, Senisterra G, Allali-Hassani A, Chau I, Dong A, Woo S, ANNABI B, Halabelian L, LaPlante SR, Vedadi M, Barsyte-Lovejoy D, Santhakumar V, Gagnon A. Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid. ChemMedChem. 2021 Oct 6;16(19):2982-3002.

Hajjar R, Oliero M, Cuisiniere T, Fragoso G, Calvé A, Djediai S, ANNABI B, Richard CS, Santos MM. Improvement of colonic healing and surgical recovery with perioperative supplementation of inulin and galacto-oligosaccharides. Clin Nutr. 2021 Jun;40(6):3842-3851.

AbuSarah J., Cui Y., EL-Hachem N., El-Kadiry AE, Martel IH, Wurtele H, Beaudry A, Raynal N, Robert F, Pelletier J, Jankovic M, Mercier F, Kamyabiazar S, ANNABI B., Rafei M. (2021) TACIMA-218: A novel pro-oxidant agent exhibiting selective anti-tumoral activity.  Molecular Cancer Therapeutics  20(1):37-49