Angelo Calderone



Titre:

Professeur titulaire
Département de pharmacologie et physiologie
Faculté de médecine
Université de Montréal

Adresse: Institut de Cardiologie de Montréal
5000 Est, rue Bélanger
Montréal (Québec) H1T 1C8
Local: S-3320
Téléphone: 514 376-3330, poste 3170
Courriel: angelo.calderone@umontreal.ca


Formation

  • B.Sc. Biochimie , McGill University (1986)
  • Ph.D. Physiologie , Université de Montréal, (1992)
  • Stage post-doctoral, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA (1995)

Thèmes de recherche

  • Remodelage et Régénération Cardiaque

Approches techniques

  • Modèles de rat/souris de l’infarctus myocarde, pression surcharge, diabète type I et transplantation cellulaire.
  • Culture cellulaire des cardiomyocytes des rats nouveau-nés, les fibroblastes ventriculaires et les cellules muscle lisse vasculaire.
  • Immunofluorescence, lentivirus, adénovirus, Western.

Membre du laboratoire

  • Vanessa Hertig (MSc), assistante de recherche

Publications

Hertig V, Matos-Nieves A, Garg V, Villeneuve L, Mamarbachi M, Caland L, Calderone A. Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis. J Cell Physiol. 2018 Apr;233(4):3218-3229. doi: 10.1002/jcp.26165. Epub 2017 Sep 27.

Calderone A. The Biological Role of Nestin(+)-Cells in Physiological and Pathological Cardiovascular Remodeling. Front Cell Dev Biol. 2018 Feb 14;6:15. doi: 10.3389/fcell.2018.00015. eCollection 2018.

Meus MA, Hertig V, Villeneuve L, Jasmin J-F, Calderone A. Nestin expression by pre-existing cardiomyocytes recapitulated in part an embryonic phenotype; suppressive role of p38 MAPK. J Cellular Physiology. 2017 Jul;232(7):1717-1727

Calderone A. p38 MAPK and the compromised regenerative response of the infarcted adult heart. Cardiovascular Regenerative Medicine 2017; 4: e1508. doi: 10.14800/crm.1508. http://www.smartscitech.com/index.php/crm.

Hertig V, Tardif K, Meus MA, Duquette N, Villeneuve L, Toussaint F, Ledoux J, Calderone A. Nestin expression is upregulated in the fibrotic rat heart and is localized in collagen-expressing mesenchymal cells and interstitial CD31(+)-cells. PLOS One, 12(4):e0176147, 2017.

Hertig V, Nieves AM, Garg V, Villeneuve L, Mamarbachi M, Caland L, Calderone A. Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis. Journal of Cellular Physiology, 2018 Apr;233(4):3218-3229.

Calderone A. The biological role of nestin(+)-cells in physiological and pathological cardiovascular remodelling. Frontiers in Cell & Developmental Biology, 2018 (Accepted)