Anne Marinier

Formation

• B.Sc. en chimie (1985)
• M.Sc. en chimie organique (1987)
• Ph.D. en chimie organique (1990)
• Post-doctorat en synthèse organique (1991)

Publications récentes

• Baccelli I, Krosl J, Boucher G, Boivin I, Lavallée VP, Hébert J, Lemieux S, Marinier A, Sauvageau G.
  A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens. Blood Cancer J. (2017), 7(2):e529. doi: 10.1038/bcj.2017.10. 17 février 2017.
• Wong PC, Seiffert D, Bird JE, Watson CA, Bostwick J, Giancarli M, Allegretto N, Hua J, Harden, Guay J, Callejo M, Miller MM, Lawrence RM, Banville J, Guy J, Maxwell B, Priestley ES, Marinier A, Wexler RR, Bouvier M, Gordon DA, Schumacher WA, Yang J. Blockade of protease-activated receptor-4 (PAR4) as a novel antiplatelet target with strong efficacy and low bleeding liability. Science Translational Medicine (2017), 9(371) 4 janvier 2017.
• Gerby B, Veiga VFT, Krosl J, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok BH, Roux PP, Hoang T.
  High-throughput screening in niche-based assay identifies compounds to target preleukemic cells. Journal of Clinical Investigation (2016),126(12): 4391-4741 1 décembre 2016.
• Normandin K, Lavallée JF, Futter M, Beautrait A, Duchaine J, Guiral S, Marinier A, Archambault V. Identification of Polo-like kinase -1 interaction inhibitors using a novel cell-based assay. Scientific Reports (2016), 5: 37581. doi:10.1038/srep37581 22 novembre 2016.
• Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G. Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors. Blood (2016),127: 3054-3061 16 juin 2016.
• Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G. The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias. Nat Genet. (2015), 47(9): 1030-7. 3 août 2015.
• Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien M. Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation. Nat Struct Mol Biol. (2015), 22(1): 37-43. 1 décembre 2014.
• Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp JHF D, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G. Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science (2014), 345(6203): 1509-12. 19 septembre 2014.
• Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G. Identification of small molecules that support human leukemia stem cell activity ex vivo. Nature methods (2014), 11(4): 436-442. 23 février 2014.